NQO1 is a multifaceted enzyme with roles in cellular defense, redox regulation, and various metabolic processes. Its ability to respond to cellular stress and its potential involvement in aging and neurodegenerative diseases highlight its importance in human health
NQO1, a versatile enzyme, plays multiple roles in cellular health and disease. While it is well-known for its ability to detoxify harmful compounds, recent research has unveiled its broader functions, including protein interactions, RNA binding, and redox sensing. NQO1’s protective role against oxidative stress and its overexpression in many cancers have made it a target for therapeutic interventions. Furthermore, NQO1’s involvement in metabolic disorders like type 2 diabetes and Alzheimer’s disease is increasingly recognized. Its potential role in lifespan extension remains an intriguing area of research. The ability of NQO1 to respond to changes in cellular redox state suggests its function as a redox sensor, opening up new avenues for understanding redox-dependent signaling pathways.
https://www.sciencedirect.com/science/article/pii/S2213231721000987
