Mitochondrial and Metabolic Dysfunction in Aging and Age-Related Diseases

Wellness Begins at the Mitochondrial Level

Aging is closely tied to mitochondrial decline, which weakens energy production, raises oxidative stress, and disrupts genome stability, metabolism, and cellular repair. These changes contribute to major age‑related diseases such as type 2 diabetes, cardiovascular disease and more.  The article explains that lifestyle strategies like exercise and calorie restriction, along with various pharmaceutical drugs such as NAD⁺ boosters and targeted antioxidants, can help restore mitochondrial function and improve metabolic health. However, turning these approaches into reliable therapies remains difficult because mitochondrial biology and ageing are highly complex and interconnected.

https://pubmed.ncbi.nlm.nih.gov/35145250