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Mild oxidative stress may not be a factor limiting longevity. Changes in genetics and the environment can make organisms like nematodes live longer. In a particular worm called C. elegans, being exposed to low radiation, short-term heat, and high oxygen levels has been shown to extend their lifespan, likely because they adapt to tough conditions. This […]
NRF2 plays a vital role in controlling a complex network of functions. Ranging from how our cells process food for energy, to the adept handling of stress. Nrf2 (nuclear factor erythroid 2-related factor 2) transcription factor is a key player in the homeostasis process as one of the primary regulators of cellular response to environmental […]
Oxidative Stress: Harms and Benefits: Oxidative stress is a phenomenon caused by an imbalance of oxygen reactive species (ROS) in cells and tissues. ROS play several physiological roles (i.e., cell signaling), and they are normally generated as by-product of oxygen metabolism; despite this, environmental stressors (i.e., UV, ionizing radiations, pollutants, and heavy metals) contribute to […]
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Redox regulation, gene expression and longevity
Mild oxidative stress may not be a factor limiting longevity. Changes in genetics and the environment can make organisms like nematodes live longer. In a particular worm called C. elegans, being exposed to low radiation, short-term heat, and high oxygen levels has been shown to extend their lifespan, likely because they adapt to tough conditions. This […]
NRF2, a Transcription Factor for Stress Response and Beyond
NRF2 plays a vital role in controlling a complex network of functions. Ranging from how our cells process food for energy, to the adept handling of stress. Nrf2 (nuclear factor erythroid 2-related factor 2) transcription factor is a key player in the homeostasis process as one of the primary regulators of cellular response to environmental […]
Oxidative Stress: Harms and Benefits for Human Health
Oxidative Stress: Harms and Benefits: Oxidative stress is a phenomenon caused by an imbalance of oxygen reactive species (ROS) in cells and tissues. ROS play several physiological roles (i.e., cell signaling), and they are normally generated as by-product of oxygen metabolism; despite this, environmental stressors (i.e., UV, ionizing radiations, pollutants, and heavy metals) contribute to […]
Short Overview of ROS as Cell Function Regulators and Their Implications in Therapy Concepts.
It is important to maintain a balanced redox mediator environment for optimal cellular functioning as a potential therapeutic target for healing and regeneration. Reactive oxygen species (ROS) are molecules generated during normal cellular processes that can act as regulators of cellular functions. ROS play a dual role in affecting cell function and acting as mediators […]
Nrf2, the Master Regulator of Anti-Oxidative Responses
Nrf2 plays a crucial role in inflammation by helping our body produce antioxidants. Nrf2 acts as a regulator and can turn on/off certain genes when needed, helping to detoxify and protect against harmful substances. The nuclear factor erythroid 2-like 2 (Nrf2) is a key factor in maintaining a balanced immune response and avoiding chronic inflammation. […]
Hydrogen peroxide as a signal for skeletal muscle adaptations to exercise: What do concentrations tell us about potential mechanisms?
Hydrogen peroxide plays a crucial role in cell signaling, triggering positive changes in muscle strength and endurance during exercise. Hydrogen peroxide helps send signals for various processes, such as making our muscles stronger and more efficient during exercise. When we exercise, our muscles undergo positive changes like increased strength and endurance that are triggered by […]
Redox Theory of Aging
The theory of aging states that aging is the decline of the body’s interconnected redox-dependent systems. The article Redox Theory of Aging explains that aging is a decline in the interaction between the genome, environmental exposures, and responses of an organism. In this manner, oxidative stress and the imbalance of cellular redox reactions contribute significantly to an […]
Epigenetics and Aging
Environmental factors such as stress and diet can impact our epigenome, which in turn affects the aging process. Epigenetic changes play a significant role in the aging process affecting various aspects of our genome. These changes alter the accessibility of genetic material, leading to disease and decreasing longevity. Lifespan is largely influenced by epigenetic factors rather […]
Telomeres and age-related disease: how telomere biology informs clinical paradigms
Understanding how telomeres work and their impact on our cells’ health has the potential to revolutionize medical practices. Telomeres, a structure involved in protecting the ends of chromosomes, have become crucial in understanding age-related disorders. With recent advancements in science, researchers have been developing new treatments for varying conditions related to telomere length. Researchers use telomere length […]