The Redox Balance in the Prefrontal Cortex

Exercise vs. Overfeeding: Balancing Brain Health in the Prefrontal Cortex

This study investigates how our lifestyle choices—specifically what we eat and how much we move—affect the redox balance in the prefrontal cortex, the part of the brain responsible for complex thinking and decision-making. Redox balance refers to the equilibrium between harmful molecules called free radicals (oxidants) and the protective antioxidants that neutralize them. When we overeat, this balance is disrupted, leading to oxidative stress. This stress can damage brain cells and impair the brain’s ability to function properly, essentially creating a toxic environment for our neurons.

https://www.nature.com/articles/s41598-025-99303-2