Redox interventions to Increase Exercise Performance

Compounds like NAC and Beetroot Juice Can Redefine Exercise Performance

This article explores the complex relationship between the balance of oxidants and antioxidants in the body and exercise performance. Skeletal muscles constantly produce reactive oxygen species (ROS) and nitric oxide (NO), which have both positive and negative effects on muscle function and endurance. Strenuous exercise significantly increases ROS and NO production, potentially limiting performance. The article sheds light on the use of antioxidants, such as vitamins C and E, which can have mixed results, sometimes hindering performance by reducing the beneficial effects of oxidative stress during recovery. In contrast, compounds like NAC (N-acetylcysteine) have shown promise in delaying fatigue and enhancing endurance. In addition, dietary nitrate supplementation (e.g., from beetroot juice), has been shown to increase nitric oxide bioavailability. The article concludes that supplements like NAC and dietary nitrates show promise in enhancing exercise performance.

https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP270653