ROS: From Villains to Vital Muscle Signalers
This research investigates the dual role of reactive oxygen species (ROS) in skeletal muscle adaptation, revealing that ROS are not merely harmful but also crucial signaling molecules. Both exercise and a sedentary life elevate ROS levels in muscles, initially thought to be damaging. However, ROS are now understood to influence signaling pathways that drive muscle changes in response to physical activity or rest. The study examines ROS production sites within muscle cells and their interaction with signaling pathways, including kinases, phosphatases, and the NF-κB transcription factor, affecting gene expression and muscle structure. The article highlights how moderate ROS increases during short exercise spurring muscle growth and protection.
https://physoc.onlinelibrary.wiley.com/doi/10.1113/expphysiol.2009.050526
