KCTD proteins may play a significant role in cancer diagnosis and treatment.
The human family of KCTD proteins consists of 25 members, many of which are not fully understood yet. Some KCTDs are linked to neurological disorders or obesity. Recently, more KCTDs are being associated with cancer-related traits or influencing cancer pathways. This suggests that understanding these proteins better could help in treating cancer or using them as markers for diagnosis or predicting how the disease might progress. These proteins share similarities and can help break down and remove other proteins, can team up with each other, and are involved in important communication pathways in both normal development and cancer. The review suggests that more KCTD proteins than currently known could play significant roles in cancer, either promoting it or fighting it, indicating a need for more research in this area.
https://biosignaling.biomedcentral.com/articles/10.1186/s12964-021-00737-8
