Manipulating Nrf2 and NF-κB Signaling: A Promising Frontier for Safeguarding Against Drug-Induced Toxicity.
Many drugs, like overuse of APAP (Acetaminophen) and cancer treating agents, can harm organs, limiting their use in clinical treatment. We don’t fully understand how these drugs damage tissues or how to protect against it. There’s growing interest in the Nrf2, the master antioxidant switch, and NF-κB, a protein associated with inflammatory reactions, signaling pathways in this context. This text discusses how imbalances in Nrf2 and NF-κB can worsen toxicity related to such drugs. Some botanical substances such as quercetin and curcumin can restore Nrf2 activity, reducing harm and inflammation caused by NF-κB. Targeting this balance with botanical components looks promising for treating drug-induced toxicity in the future.