Redox regulation, gene expression and longevity

Mild oxidative stress may not be a factor limiting longevity. 

Changes in genetics and the environment can make organisms like nematodes live longer. In a particular worm called C. elegans, being exposed to low radiation, short-term heat, and high oxygen levels has been shown to extend their lifespan, likely because they adapt to tough conditions. This suggests that mild oxidative stress might lead to adaptations that contribute to an organism’s resilience and consequently can have a positive effect on lifespan.