NRF2 plays a vital role in controlling a complex network of functions. Ranging from how our cells process food for energy, to the adept handling of stress.
Nrf2 (nuclear factor erythroid 2-related factor 2) transcription factor is a key player in the homeostasis process as one of the primary regulators of cellular response to environmental stressors, such as toxins and oxidative stress. Homeostasis, which is the ability to maintain a stable internal environment despite external changes, is crucial to the health and survival of all organisms. Further understanding of homeostasis has led to extensive research into NRF2’s role in cancer prevention and treatment, as well as inflammation and metabolism, demonstrating its functions are more far-reaching than initially thought. Hence, a deeper comprehension of NRF2’s regulatory activities and its emerging roles open new opportunities for disease therapeutics.