Nrf2 Mediates Redox Adaptation to Exercise

Exercise boosts our master antioxidant defense system, Nrf2, across various tissues, promoting overall health benefits.

This review explores how exercise impacts a master regulator called Nrf2, which controls many genes for antioxidant defenses. Exercise triggers Nrf2, boosting our body’s ability to fight free radicals. Importantly, Nrf2 activation does not only occur in muscles, but across various tissues, suggesting it plays a key role in exercise’s overall health benefits. Findings from animal studies suggest that Nrf2 activation is a promising area for understanding and maximizing the positive effects of exercise in humans.