Stem Cells, Redox Signaling, and Stem Cell Aging

Redox signaling molecules play a beneficial role in stem cell aging.

The connection between functional stem cell decline and the loss of tissue homeostasis leads to aging-related diseases. Recent advances highlight the role of redox metabolism in controlling the stem cell pool and aging. While reactive oxygen species (ROS) are typically known for causing cellular damage, emerging evidence suggests they play a beneficial role in physiological signaling in stem cells. This review focuses on signaling pathways and transcription factors regulated by ROS, influencing stem cell fate and potentially contributing to diseases of stem cell aging. Future research aims to understand how ROS control stem cell cycling, apoptosis, and lineage determination, providing insights into mechanisms underlying stem cell aging.