The Role of Nrf2 in Pulmonary Fibrosis

Nrf2 as a Molecular Weapon for Pulmonary Fibrosis Disease

Pulmonary fibrosis is a lung disease and a global health issue. Despite advances in the understanding of this disease, there are still no effective methods in treatment and prevention. Nrf2 is now a potential target for treatment, giving support to the body to fight inflammation by acting at the cellular level.  Some studies show that activating Nrf2 can reduce fibrosis and help with lung scarring. This review shows how Nrf2 works in pulmonary fibrosis and how it might be used to develop new therapies. Nrf2 seems to control many protective genes that fight inflammation, oxidative stress, and other processes involved in pulmonary fibrosis.