NRF2 – A Regulator of Keratinocyte Redox Signaling

Understanding the role of Nrf2 in skin health: How this master regulator maintains skin integrity and protects against oxidative damage

Oxidative stress, caused by an imbalance between the production and removal of reactive oxygen species (ROS), is linked to various human disorders. ROS, produced during normal cell processes, can damage cells and trigger inflammation or cancer when excessive exposure occurs. Cells use antioxidants and detoxifying enzymes, regulated by Nrf2, to counteract ROS damage. This protective mechanism is also crucial in the skin, especially when facing challenges like UV exposure and toxins. Nrf2 helps maintain skin integrity by regulating cytoprotective proteins, including glutathione, in keratinocytes, the main cell type in the skin’s outer layer. This process ensures a healthy skin barrier.