Dissecting the Crosstalk Between Nrf2 and NF-κB Response Pathways in Drug-Induced Toxicity
Manipulating Nrf2 and NF-κB Signaling: A Promising Frontier for Safeguarding Against Drug-Induced Toxicity. Many drugs, like overuse of APAP (Acetaminophen)…
Redox regulation, gene expression and longevity
Mild oxidative stress may not be a factor limiting longevity. Changes in genetics and the environment can make organisms like…
NRF2, a Transcription Factor for Stress Response and Beyond
NRF2 plays a vital role in controlling a complex network of functions. Ranging from how our cells process food for…
Oxidative Stress: Harms and Benefits for Human Health
Oxidative Stress: Harms and Benefits: Oxidative stress is a phenomenon caused by an imbalance of oxygen reactive species (ROS) in…
Short Overview of ROS as Cell Function Regulators and Their Implications in Therapy Concepts.
It is important to maintain a balanced redox mediator environment for optimal cellular functioning as a potential therapeutic target for…
Nrf2, the Master Regulator of Anti-Oxidative Responses
Nrf2 plays a crucial role in inflammation by helping our body produce antioxidants. Nrf2 acts as a regulator and can…
Hydrogen peroxide as a signal for skeletal muscle adaptations to exercise: What do concentrations tell us about potential mechanisms?
Hydrogen peroxide plays a crucial role in cell signaling, triggering positive changes in muscle strength and endurance during exercise. Hydrogen…
Redox Theory of Aging
The theory of aging states that aging is the decline of the body’s interconnected redox-dependent systems. The article Redox Theory of…
Epigenetics and Aging
Environmental factors such as stress and diet can impact our epigenome, which in turn affects the aging process. Epigenetic changes…
Telomeres and age-related disease: how telomere biology informs clinical paradigms
Understanding how telomeres work and their impact on our cells’ health has the potential to revolutionize medical practices. Telomeres, a structure…